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Condensation reactions between 2-phenylthio-2,3-dideoxyribose derivatives and nucleic bases
H Kawakami1, T Ebata, K Koseki
1Life Science Research Laboratory, Japan Tobacco Inc., Kanagawa.
Nucleic Acids Symposium Series
|January 1, 1991
Abstract:
The effects of phenylthio group at C-2 of 2,3-dideoxyribose were examined for the stereoselectivities in condensation reactions between sugars and pyrimidine bases. In the case of mono-PhS sugar, the 1,2-trans-anomers were mainly obtained in the ratio of 9:1. Condensation reactions with di-PhS-sugar gave the anomeric mixtures of alpha:beta = 2:8.