Related Experiment Video
Updated: Jul 5, 2026
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
Animal models of Vogt-Koyanagi-Harada disease (sympathetic ophthalmia)
Kunihiko Yamaki1, Shigeaki Ohono
1Department of Ophthalmology, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan. kyamaki@nms.ac.jp
Background/Aims:
We aimed to establish the animal model of Vogt-Koyanagi-Harada disease (VKH).
Methods:
Rats, Akita dogs and monkeys were immunized with the peptides derived from tyrosinase-related protein 1. Each experimental animal was examined clinically and histologically.
Results And Conclusion:
The rats developed ocular and extraocular inflammation homologous to human VKH by immunization of tyrosinase-related protein 1. The Akita dogs also developed the autoimmune disease almost similar to the spontaneously emerging dog VKH equivalent to human VKH. The monkeys developed similar clinical findings as human VKH. These models may serve as human VKH models.
