[Determination of dimethyl sulphate residual in granisetron hydrochloride by headspace gas chromatography]
1Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Objective:
To develop a headspace gas chromatography method for determining dimethyl sulphate residual in granisetron hydrochloride.
Methods:
An Angilent INNOWAX capillary column with nitrogen gas as carrier and FID as detector was applied in this study. Dimethyl sulphate was tested under a constant column temperature.
Result:
Dimethyl sulphate had different retention time from other organic solvents such as alcohol,acetoacetate, isopropanol, dichlormethane and chloroform, which might exist in granisetron hydrochloride. The detection limit of dimethyl sulphate;s was 0.0016%.
Conclusion:
The method can be used for the determination of dimethyl sulphate residual in granisetron hydrochloride.
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