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Related Concept Videos

Karyotyping01:17

Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
Karyotyping01:17

Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Related Experiment Video

Updated: Jul 5, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
09:16

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

Prenatal diagnosis using array CGH.

Catherine D Kashork1, Aaron Theisen, Lisa G Shaffer

  • 1Signature Genomics Laboratories, LLC, Spokane, WA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|April 22, 2008
PubMed
Summary
This summary is machine-generated.

Array comparative genomic hybridization (CGH) offers rapid, high-resolution prenatal diagnosis for genetic syndromes linked to genomic copy number variations. This reproducible method provides reliable results within five days, aiding in the detection of chromosomal abnormalities.

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Area of Science:

  • Genetics
  • Genomic Medicine
  • Prenatal Diagnostics

Background:

  • Genetic syndromes often involve gains or losses in the human genome.
  • Microarray-based comparative genomic hybridization (array CGH) is an established diagnostic tool for postnatal genetic disorder identification.
  • Existing methods for prenatal diagnosis may lack the resolution or speed required for timely intervention.

Purpose of the Study:

  • To evaluate the utility of array CGH for the prenatal diagnosis of chromosomal syndromes.
  • To assess array CGH's effectiveness in identifying congenital malformations detectable by ultrasound.
  • To determine the reproducibility and turnaround time of array CGH in a clinical prenatal setting.

Main Methods:

  • Utilized microarray-based comparative genomic hybridization (array CGH) for genomic analysis.
  • Applied the technology to prenatal samples to detect chromosomal abnormalities.
  • Focused on identifying syndromes associated with congenital malformations visible via ultrasound.

Main Results:

  • Array CGH demonstrated high resolution and speed in diagnosing genetic syndromes.
  • The technology proved reproducible and yielded reliable results within approximately five days.
  • Successfully applied array CGH for prenatal diagnosis of chromosomal syndromes linked to congenital malformations.

Conclusions:

  • Array CGH is a valuable tool for the prenatal diagnosis of chromosomal abnormalities.
  • The technology offers a rapid and reliable method for detecting genetic syndromes associated with congenital malformations.
  • Array CGH has the potential to become a primary method for prenatal genetic screening.