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Searching the MINT database for protein interaction information.

Gianni Cesareni1, Manuela Helmer-Citterich

  • 1University of Rome Tor Vergata, Rome, Italy.

Current Protocols in Bioinformatics
|April 23, 2008
PubMed
Summary
This summary is machine-generated.

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The Molecular Interactions Database (MINT) provides curated protein interaction data from scientific literature. It currently contains over 3000 interactions for 4300 proteins, focusing on mammalian species.

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Biochemistry

Background:

  • Protein interactions are fundamental to cellular processes.
  • Comprehensive databases are crucial for understanding complex biological networks.
  • Existing resources may lack detailed, curated interaction data.

Purpose of the Study:

  • To introduce the Molecular Interactions Database (MINT) as a resource for protein interaction data.
  • To describe the curation process and scope of the MINT database.
  • To provide access methods for MINT data.

Main Methods:

  • Expert curators extract protein interaction information from scientific literature.
  • Data is stored in a relational database format.
  • A web-based tool, MINT Viewer, is provided for data retrieval.

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Main Results:

  • MINT contains information on over 4300 proteins and more than 3000 interactions as of April 2003.
  • The database primarily focuses on protein interactions in mammalian species.
  • Protocols for internet-based searching of MINT are available.

Conclusions:

  • MINT serves as a valuable, curated resource for protein-protein interaction data.
  • The database facilitates research in molecular biology and systems biology.
  • Accessible data retrieval through MINT Viewer enhances usability for researchers.