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Detergent Purification of Membrane Proteins01:18

Detergent Purification of Membrane Proteins

Detergents are used to purify the integral proteins of the membrane. The hydrophobic portion of the detergent can replace membrane phospholipids while solubilizing the membrane proteins. When detergent monomers reach a specific concentration in a solution called critical micelle concentration (CMC), they form micelles. Above CMC, the concentration of the detergent monomers remains in equilibrium with the micelle. The number of detergent monomers present in the CMC varies for each detergent, and...
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Related Experiment Video

Updated: Jul 5, 2026

Contrast-Matching Detergent in Small-Angle Neutron Scattering Experiments for Membrane Protein Structural Analysis and Ab Initio Modeling
10:27

Contrast-Matching Detergent in Small-Angle Neutron Scattering Experiments for Membrane Protein Structural Analysis and Ab Initio Modeling

Published on: October 21, 2018

Commonly used detergents.

J E Coligan1

  • 1National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.

Current Protocols in Protein Science
|April 23, 2008
PubMed
Summary
This summary is machine-generated.

This appendix provides a list of common detergents, detailing their hydrophilic group type, critical micelle concentration (CMC), and micelle molecular weight for researchers.

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Area of Science:

  • Biochemistry
  • Physical Chemistry
  • Materials Science

Background:

  • Detergents are crucial amphipathic molecules used in various scientific applications.
  • Understanding detergent properties is essential for experimental design and reproducibility.

Purpose of the Study:

  • To compile a comprehensive list of commonly used detergents.
  • To provide key physicochemical properties for each detergent, including hydrophilic group classification, CMC, and micelle molecular weight.

Main Methods:

  • Data compilation from scientific literature and chemical databases.
  • Categorization of detergents based on their hydrophilic group (anionic, cationic, amphoteric, nonionic).

Main Results:

  • A detailed table of common detergents with their properties.
  • Information on critical micelle concentration (CMC) values for micelle formation.
  • Data on the molecular weight of detergent micelles.

Conclusions:

  • This resource serves as a practical guide for selecting appropriate detergents.
  • The provided data facilitates the optimization of experiments involving detergents.