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Published on: July 2, 2013
Right hemisphere involvement in non-fluent primary progressive aphasia
Claudia Repetto1, Rosa Manenti, Maria Cotelli
1IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy. claudia.repetto@cognitiveneuroscience.it
This study details a right-handed man with non-fluent primary progressive aphasia (NfPPA). Unexpectedly, his condition involved right hemisphere hypoperfusion, suggesting NfPPA can stem from the non-dominant hemisphere.
Area of Science:
- Neurology
- Neuropsychology
- Neuroimaging
Background:
- Primary progressive aphasia (PPA) is a neurodegenerative disorder affecting language.
- Non-fluent variant (NfPPA) typically involves left hemisphere language networks.
Observation:
- A 56-year-old right-handed male presented with NfPPA.
- Neuropsychological testing revealed typical NfPPA cognitive deficits.
- SPECT imaging showed hypoperfusion in the right frontal cortex.
Findings:
- This case demonstrates crossed aphasia in NfPPA, where the right hemisphere is affected in a right-handed individual.
- The findings challenge the traditional view of NfPPA localization.
Implications:
- NfPPA can result from pathology in the non-language-dominant hemisphere.
- This broadens the understanding of neuroanatomical substrates for PPA.
- Highlights the importance of considering atypical hemispheric involvement in PPA diagnosis.
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