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Updated: Jul 5, 2026
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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
The TRAMP mouse as a model for prostate cancer
Arthur A Hurwitz1, Barbara A Foster2, James P Allison3
1SUNY Upstate Medical University, Syracuse, New York.
Current Protocols in Immunology
|April 25, 2008
Summary
The Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model closely mimics human prostate cancer development. This versatile model aids in screening prostate cancer therapies and studying metastases.
Area of Science:
- Oncology
- Cancer Biology
- Animal Models
Background:
- The Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model is a valuable tool for studying prostate cancer pathogenesis.
- TRAMP mice spontaneously develop prostate tumors similar to human disease, driven by SV40 T antigen expression.
- Established TRAMP-derived cell lines enable ectopic tumor induction in syngeneic hosts.
Purpose of the Study:
- To detail the utility of the TRAMP model for prostate cancer research.
- To describe the establishment and application of TRAMP-derived cell lines for therapeutic screening.
- To provide methodologies for tumor evaluation and analysis within the TRAMP model.
Main Methods:
- Utilizing male TRAMP mice that spontaneously develop autochthonous prostate tumors.
- Establishing and employing TRAMP-derived prostate tumor cell lines for ectopic tumorigenesis.
- Developing murine models for screening primary tumor therapies and adjunctive metastatic treatments.
- Describing techniques for harvesting, microdissection, and scoring of TRAMP prostates and tumors.
Main Results:
- The TRAMP model accurately reflects human prostate cancer progression.
- TRAMP-derived cell lines facilitate the creation of models for therapy screening.
- Two distinct murine models are presented for evaluating primary and metastatic prostate cancer treatments.
- Standardized methods for tumor analysis are provided.
Conclusions:
- The TRAMP model and its derived cell lines offer a robust platform for prostate cancer research.
- These models are crucial for advancing the development of novel prostate cancer therapies.
- The provided methodologies ensure consistent and reliable evaluation of experimental treatments.
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