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In Vitro Functional Analysis of Regulatory T cells: Focus On Proliferation And Differentiation
Published on: June 9, 2026
In vitro models of human T cell anergy
Leonard J Appleman1, Vassiliki Boussiotis
1Harvard Medical School, Boston, Massachusetts, USA.
Current Protocols in Immunology
|April 25, 2008
Abstract:
T cell anergy (acquired unresponsiveness) is an important mechanism for tolerance of self antigens. Human helper T cell clones rendered anergic in vitro are valuable tools for studying the molecular mechanisms of T cell tolerance. This unit outlines the induction and assessment of anergy in human CD4+ helper T cell clones that are reactive against MHC class II alloantigens.
