Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemostatic variables in nephrotic patients.

M Cucuianu1, M Manasia, C Spînu

  • 1Institute of Public Health, Department of Nephrology, First Medical Clinic, Cluj-Napoca, Romania.

Romanian Journal of Internal Medicine = Revue Roumaine De Medecine Interne
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can Esophageal Anatomy Help to Choose Between Functional Luminal Imaging Probe (FLIP) and Barium Esophagogram in Achalasia?

Neurogastroenterology and motility·2026
Same author

Dual role of HTC products from olive tree prunings in soil: Agricultural amendment or biopesticide depending on phytotoxicity.

Waste management (New York, N.Y.)·2025
Same author

THE GAP BETWEEN GUIDELINES AND PRACTICE: THE NEED TO DE-ESCALATE INTENSITY OF TREATMENT FOR DIFFERENTIATED THYROID CANCER.

Acta endocrinologica (Bucharest, Romania : 2005)·2025
Same author

Physically stable yet biologically sensitive: multiyear ecological dynamics of anoxygenic phototrophs in stably redox-stratified Lake Cadagno.

Aquatic sciences·2025
Same author

The Role of <i>Polycystic Kidney Disease-Like</i> Homologs in Planarian Nervous System Regeneration and Function.

Integrative organismal biology (Oxford, England)·2024
Same author

Whole-Exome Sequencing identified Olfactory Receptor genes as a key contributor to extreme obesity with progression to nonalcoholic steatohepatitis in Mexican patients: Olfactory receptor genes in obese NASH patients.

Annals of hepatology·2022
Same journal

Severe Persistent Hypereosinophilia of Undetermined Significance: Diagnostic Challenges in Clinical Practice and Two-Year Follow-Up.

Romanian journal of internal medicine = Revue roumaine de medecine interne·2026
Same journal

Immune Checkpoint Inhibitor-Associated Myocarditis: A Retrospective Case Series.

Romanian journal of internal medicine = Revue roumaine de medecine interne·2026
Same journal

Mortality predictors in patients with ST-segment elevation myocardial infarction presenting no-reflow phenomenon after primary PCI: experience of a tertiary center.

Romanian journal of internal medicine = Revue roumaine de medecine interne·2026
Same journal

Pancreatic stone protein predicts hospital stay in community-acquired infections.

Romanian journal of internal medicine = Revue roumaine de medecine interne·2026
Same journal

Clinical features and hematological indices predicting all-cause mortality in patients undergoing hemodialysis; a retrospective cohort study.

Romanian journal of internal medicine = Revue roumaine de medecine interne·2026
Same journal

Clinical construct validity and subgroup stability of the Romanian version of the Boston Carpal Tunnel Questionnaire in nerve-conduction-confirmed carpal tunnel syndrome - a cross-sectional study.

Romanian journal of internal medicine = Revue roumaine de medecine interne·2026
See all related articles

Nephrotic syndrome disrupts hemostasis, increasing thrombotic risk due to altered clotting factors and platelet function. Compensatory mechanisms like protein C and tissue plasminogen activator (t-PA) may be overwhelmed, leading to a precarious balance.

Area of Science:

  • Nephrology
  • Hematology
  • Thrombosis Research

Background:

  • Nephrotic syndrome is characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia.
  • Patients with nephrotic syndrome exhibit an increased risk of thromboembolic events.
  • The hemostatic balance in nephrotic patients is complex and not fully understood.

Purpose of the Study:

  • To review and analyze the hemostatic balance in nephrotic patients.
  • To investigate the prothrombotic and antithrombotic factors in nephrotic syndrome.
  • To elucidate the mechanisms contributing to the thrombotic tendency in this condition.

Main Methods:

  • Literature review of existing data.
  • Analysis of authors' own investigations over seven years.

Related Experiment Videos

  • Assessment of plasma levels of coagulation factors, inhibitors, and platelet aggregability.
  • Evaluation of the fibrinolytic system's behavior.

    • Main Results:

    • Elevated plasma levels of fibrinogen, fibronectin, factor XIII, factors V and VIII, and von Willebrand factor.
    • Increased platelet aggregability and decreased plasma antithrombin III.
    • Enhanced tissue plasminogen activator (t-PA) release with accelerated clot lysis, despite increased fibrinolytic inhibitors.
    • Increased plasma protein C levels, suggesting a compensatory antithrombotic mechanism.

    Conclusions:

    • Nephrotic syndrome presents a prothrombotic state due to altered hemostatic factors and platelet function.
    • Compensatory antithrombotic mechanisms, including protein C and t-PA, exist but may be insufficient.
    • Urinary loss of antithrombin III and enhanced hepatic synthesis of clotting factors contribute to the precarious hemostatic balance and thrombotic risk.