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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Related Experiment Video

Updated: Jul 5, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

Oral antibiotics decrease urinary isoflavonoid excretion in children after soy consumption.

Brunhild M Halm1, Adrian A Franke, Leslie A Ashburn

  • 1Cancer Research Center of Hawai'i, Cancer Prevention & Control Program and Kapi'olani Medical Center for Women and Children, Honolulu, HI 96813, USA.

Nutrition and Cancer
|April 30, 2008
PubMed
Summary
This summary is machine-generated.

Oral antibiotics (OABX) significantly reduce urinary isoflavone excretion rates (UIERs) in soy-consuming children. This suggests OABX alter gut bacteria, impacting how the body processes beneficial soy compounds.

Related Experiment Videos

Last Updated: Jul 5, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

Area of Science:

  • Human Nutrition and Metabolism
  • Microbiology and Gut Health
  • Pharmacology

Background:

  • Isoflavones (IFLs) are plant compounds found in soy with potential health benefits.
  • The gut microbiome plays a crucial role in metabolizing IFLs.
  • The impact of oral antibiotics (OABX) on IFL metabolism in children is not well understood.

Purpose of the Study:

  • To investigate how OABX affect urinary isoflavone excretion rates (UIERs) in children who consume soy.
  • To explore the potential role of gut microflora alterations in mediating these effects.

Main Methods:

  • A cohort of 11 children (ages 4-17) provided paired urine samples: one during OABX treatment and one when healthy.
  • Participants consumed a standardized dose of soy nuts.
  • Urinary IFLs (nonmetabolites and metabolites) were quantified using liquid chromatography-mass spectrometry.

Main Results:

  • Urinary excretion rates for genistein (GE), other nonmetabolite IFLs, and total IFLs were significantly lower during OABX treatment compared to when healthy (P < 0.05).
  • A trend towards increased O-desmethylangolensin (DMA) production was observed during OABX use (P = 0.13).
  • Reduced IFLs in urine may be linked to OABX-induced changes in gut bacteria or infection-related processes.

Conclusions:

  • Oral antibiotic use significantly decreases the urinary excretion of isoflavones in soy-consuming children.
  • This reduction highlights the influence of the gut microbiome on IFL bioavailability and metabolism.
  • Further research is needed to fully elucidate the mechanisms behind OABX-mediated changes in IFL processing.