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Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Synthesis of novel monodentate phosphoramidites and their application in iridium-catalyzed asymmetric hydrogenations
Giulia Erre1, Kathrin Junge, Stephan Enthaler
1Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.
Abstract:
New monodentate H(8)-binaphthol based phosphoramidites 6 b-i have been prepared. Starting from (S)-3,3'-dibromo-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diol 3, a general protocol for the synthesis of ligands 6 is presented. A small ligand library bearing aryl substituents in the 3,3'-position of the binaphthol core was synthesized and successfully tested in the iridium-catalyzed asymmetric hydrogenation of 2-amidocinnamates to obtain different alpha-amino acid derivatives in up to 99 % ee.
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