Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High-throughput functional annotation and data mining with the Blast2GO suite.

Stefan Götz1, Juan Miguel García-Gómez, Javier Terol

  • 1Bioinformatics Department, Centro de Investigación Principe Felipe, Valencia, Spain.

Nucleic Acids Research
|May 1, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A decade of progress towards the elimination of hepatitis C: from the National Strategic Plan to Artificial Intelligence.

Gastroenterologia y hepatologia·2026
Same author

Menopause age and hypercholesterolemia comorbidities: a region-wide retrospective cohort study in Andalusia, Spain (2016-2022).

BMJ open·2026
Same author

IMPaCT-Data: A Federated Precision Medicine Infrastructure Associated with Science and Technology in Spain.

Studies in health technology and informatics·2026
Same author

TUSCO: benchmarking transcriptome reconstruction with endogenous single-isoform controls.

Nature communications·2026
Same author

High-Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million-Patient Diabetes Cohort.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Cocirculation of endemic and recently introduced West Nile Virus lineage 1 clades in Southern Spain.

One health (Amsterdam, Netherlands)·2026
Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026
Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026
Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026
Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026
Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026
See all related articles

Blast2GO provides automatic functional annotation for DNA and protein sequences using Gene Ontology. This bioinformatics tool aids researchers in interpreting functional genomics data efficiently.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • Functional genomics relies heavily on accurate DNA and protein sequence annotation.
  • Interpreting experimental results requires comprehensive functional information on gene products.
  • Existing bioinformatics resources often struggle with large datasets and accessibility for functional genomics projects.

Purpose of the Study:

  • To present Blast2GO as an integrated, biologist-oriented solution for high-throughput functional annotation.
  • To detail the features of Blast2GO, including diverse annotation strategies, graphical visualization, and sequence management.
  • To analyze annotation behavior via homology transfer and its impact on functional genomics research.

Main Methods:

  • Utilized the Blast2GO suite for automatic functional annotation of DNA and protein sequences.

Related Experiment Videos

  • Employed Gene Ontology vocabulary as the basis for annotation.
  • Integrated various annotation strategies and graphical tools for analysis and visualization.
  • Performed high-throughput analysis of annotation behavior through homology transfer.

    • Main Results:

    • Blast2GO offers integrated, automatic, and high-throughput functional annotation.
    • Key features include diverse annotation controls, interactive GO-graph visualization, and sequence management.
    • Analysis provided insights into annotation behavior and its impact on functional genomics.

    Conclusions:

    • Blast2GO is a valuable resource for biologists undertaking functional genomics projects.
    • The tool facilitates efficient functional characterization of sequence data.
    • Understanding annotation behavior is crucial for effective interpretation of functional genomics results.