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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Published on: December 15, 2011

Cold urticaria and celiac disease.

M Pedrosa Delgado¹, F Martín Muñoz, I Polanco Allué

¹Allergy Department, University Hospital La Paz, Madrid, Spain. m.pedrosa.d@gmail.com

Journal of Investigational Allergology & Clinical Immunology

|May 2, 2008

Summary

This summary is machine-generated.

Celiac disease, an autoimmune disorder, may be linked to cold urticaria, a skin reaction to cold. A gluten-free diet resolved symptoms in a child, suggesting a potential association.

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Area of Science:

Immunology
Gastroenterology
Dermatology

Background:

Cold urticaria is a condition causing hives upon cold exposure, potentially linked to various underlying issues.
Celiac disease is an autoimmune disorder triggered by gluten, often co-occurring with other autoimmune conditions.

Observation:

A pediatric case presented with cold-induced urticaria-angioedema and iron deficiency anemia.
The patient also developed sensitivities to legumes and environmental allergens, along with asthma.

Findings:

Diagnostic tests confirmed celiac disease in the patient with persistent cold urticaria and anemia.
A gluten-free diet led to the resolution of both anemia and cold urticaria symptoms.

Implications:

This case suggests a potential association between celiac disease and cold urticaria, previously undescribed.
Investigating celiac disease may be warranted in cases of refractory cold urticaria without other identifiable causes.