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Updated: Jul 5, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Brønsted acid TfOH-mediated [3 + 2] cycloaddition reactions of diarylvinylidenecyclopropanes with nitriles
1State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, China
Abstract:
Diarylvinylidenecyclopropanes undergo a [3 + 2] cycloaddition reaction with MeCN in the presence of Brønsted acid TfOH to give the corresponding 3,4-dihydro-2 H-pyrrole derivatives 2 in moderate to excellent yields under reflux within a short time. As for the diarylvinylidenecyclopropane substrate containing a strongly electron-donating methoxy group on the benzene ring, the reaction leads to the formation of a different type of 3,4-dihydro-2 H-pyrrole derivatives 4 under the same conditions.
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