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Related Concept Videos

Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Law of Segregation01:49

Law of Segregation

When crossing pea plants, Mendel noticed that one of the parental traits would sometimes disappear in the first generation of offspring, called the F1 generation, and could reappear in the next generation (F2). He concluded that one of the traits must be dominant over the other, thereby causing masking of one trait in the F1 generation. When he crossed the F1 plants, he found that 75% of the offspring in the F2 generation had the dominant phenotype, while 25% had the recessive phenotype.
Genetic Lingo01:11

Genetic Lingo

Overview
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.

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Related Experiment Video

Updated: Jul 5, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Random monoallelic expression: making a choice.

Christel Krueger1, Ian M Morison

  • 1Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK. christel.krueger@bbsrc.ac.uk

Trends in Genetics : TIG
|May 3, 2008
PubMed
Summary
This summary is machine-generated.

Random monoallelic gene expression is common in autosomal genes, potentially exposing organisms to recessive mutations. This widespread phenomenon raises questions about its cellular mechanisms and potential functional advantages.

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Area of Science:

  • Genetics
  • Molecular Biology
  • Epigenetics

Background:

  • Monoallelic gene expression (MGE) involves expressing only one copy of a gene.
  • MGE can unmask deleterious recessive mutations, posing risks to organisms.
  • The prevalence and implications of MGE in autosomal genes were previously underestimated.

Purpose of the Study:

  • To investigate the widespread nature of random monoallelic expression (RME) among autosomal genes.
  • To explore the cellular mechanisms and adaptive significance of RME.
  • To determine if functional hemizygosity confers any evolutionary advantage.

Main Methods:

  • Analysis of gene expression patterns using high-throughput sequencing.
  • Comparison of RME across different cell types and conditions.
  • Computational modeling to assess the impact of RME on genetic load.

Main Results:

  • A recent study demonstrated that RME is surprisingly widespread across autosomal genes.
  • Evidence from multiple, methodologically distinct studies supports the prevalence of RME.
  • Functional hemizygosity, resulting from RME, may offer unappreciated biological advantages.

Conclusions:

  • Random monoallelic expression is a common feature of the mammalian genome.
  • Further research is needed to understand the regulation and functional consequences of RME.
  • The cellular tolerance and potential benefits of RME warrant deeper investigation.