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Clavulanic acid: a review
Parag S Saudagar1, Shrikant A Survase, Rekha S Singhal
1Food Engineering and Technology Department, Institute of Chemical Technology, Nathalal Parikh Marg, Matunga, Mumbai 400 019, India.
Abstract:
Natural antibiotics are almost universal secondary metabolites, not essential for the growth of the producing organisms generally produced at low growth rates or after growth has ceased. Clavulanic acid (CA), a naturally occurring powerful inhibitor of bacterial beta-lactamases is a major beta-lactam antibiotic produced by organism Streptomyces clavuligerus and is active against a wide spectrum of Gram-positive and Gram-negative bacteria. The review discusses the biosynthetic pathway, fermentative production, downstream processing and applications of CA.
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