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Cholestatic hepatitis as a possible new side-effect of oxycodone: a case report
Vincent Ho1, Maxwell Stewart, Peter Boyd
1School of Medicine, James Cook University, Cairns Base Hospital, Cairns, Queensland, Australia. vincent_ho@health.qld.gov.au
Journal of Medical Case Reports
|May 3, 2008
Summary
Cholestatic hepatitis, a rare side effect, may be caused by oxycodone. This case report highlights the potential for drug-induced liver injury, emphasizing physician awareness for prompt diagnosis and management.
Area of Science:
- Hepatology
- Clinical Pharmacology
- Toxicology
Background:
- Oxycodone is a common semisynthetic opioid analgesic with established side effects.
- Cholestatic hepatitis has not been previously reported as a side effect of oxycodone.
Purpose of the Study:
- To report a case of cholestatic hepatitis potentially induced by oxycodone.
- To raise awareness among physicians about this rare adverse drug reaction.
Main Methods:
- A case presentation of a 34-year-old male with cholestatic jaundice and pruritus post-oxycodone use.
- Comprehensive laboratory and imaging studies were performed.
- Liver biopsy confirmed canalicular cholestasis suggestive of drug-induced hepatotoxicity.
Main Results:
- The patient presented with cholestatic jaundice and severe pruritus after oxycodone administration.
- Exclusion of other causes for jaundice was confirmed through extensive investigations.
- Resolution of symptoms and normalization of transaminases upon oxycodone withdrawal indicated drug causality.
Conclusions:
- Cholestatic hepatitis is a potential, albeit rare, side effect of oxycodone.
- Physicians should consider oxycodone-induced hepatotoxicity in patients presenting with cholestatic jaundice.
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