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Updated: Jul 5, 2026

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
Published on: November 25, 2017
C-5 modifications in N-acetyl-neuraminic acid: scope and limitations
Cristina De Meo1, Uvege Priyadarshani
1Department of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL 62026, USA. cdemeo@siue.edu
Abstract:
Glycoconjugates containing sialic acid are involved in a large variety of biological phenomena, including cell-cell adhesion, recognition by viruses and bacteria, and oncogenesis. Therefore, they are important synthetic targets for the design of drugs and vaccines. In the last decades, different methodologies that improve yield and stereoselectivity in sialylation reactions have been investigated. This review summarizes the latest developments in the synthesis of C-5 modified sialic acid glycosyl donors and glycosyl acceptors and their application in the synthesis of alpha-sialosides.
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