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Updated: Jul 5, 2026
09:51
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
Web-based resources for clinical bioinformatics.
Anthony M Joshua1, Paul C Boutros
1Department of Medical Oncology, Princess Margaret Hospital, Toronto, Canada.
Methods in Molecular Medicine
|May 6, 2008
Summary
This chapter introduces essential internet databases and analytical tools for molecular biologists and clinicians in the post-Human Genome Project era. It covers key resources like NCBI/Entrez and analytical methods for sequence alignment and molecular interactions.
Area of Science:
- Bioinformatics
- Genomics
- Molecular Biology
Background:
- The post-Human Genome Project era necessitates proficiency in utilizing online biological resources.
- Understanding these resources is crucial for hypothesis generation, experimental design, and data interpretation in molecular biology and clinical practice.
Purpose of the Study:
- To provide an overview of essential internet-based databases and analytical tools for researchers and clinicians.
- To facilitate the adoption and practical use of these bioinformatics resources by introducing key terminology.
Main Methods:
- Database exploration including National Center for Biotechnology Information (NCBI)/Entrez, Ensembl, and University of California Santa Cruz (UCSC) Genome Browser.
- Introduction to analytical tools for sequence alignment, promoter analysis, and molecular interaction studies.
Main Results:
- Key bioinformatics databases and their functionalities are presented.
- Essential analytical tools for molecular data interpretation are described.
Conclusions:
- Familiarity with online databases and analytical tools is vital for modern biological research and clinical applications.
- This overview aims to empower users to effectively leverage these resources for scientific discovery.
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