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Updated: Jul 5, 2026
09:41
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Sweet's syndrome associated with multiple myeloma.
Hichem Belhadjali1, Sami Chaabane, Leïla Njim
1Department of Dermatology, Fattouma Bourguiba Hospital, Monastir 5000, Tunisia. hichem@prontomail.com
Summary
Sweet's syndrome (SS), an acute febrile neutrophilic dermatosis, is rarely associated with multiple myeloma (MM). This case highlights a potential link between IgG multiple myeloma and the development of Sweet's syndrome.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Sweet's syndrome (SS) is an acute febrile neutrophilic dermatosis.
- It can be paraneoplastic in 10-20% of cases.
- Association with multiple myeloma (MM) is uncommon.
Observation:
- A 73-year-old woman developed SS two months after an IgG MM diagnosis.
- Cutaneous lesions of SS resolved rapidly following MM chemotherapy.
- No SS recurrence was observed over a two-year follow-up.
Findings:
- Only 14 cases of SS associated with MM have been reported in literature.
- The secretory status of MM may influence SS occurrence.
- SS appears to be linked to IgG MM, suggesting a higher risk in these patients.
Implications:
- This case adds to the limited literature on SS and MM.
- Further research may elucidate the specific mechanisms linking IgG MM and SS.
- Recognizing this association can aid in timely diagnosis and management of patients with both conditions.
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