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Updated: Jul 5, 2026

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores
Published on: August 19, 2013
Enantioselective fluorescence sensing of chiral alpha-amino alcohols
Shuanglong Liu1, John Paul C Pestano, Christian Wolf
1Department of Chemistry, Georgetown University, Washington, DC 20057, USA.
Abstract:
1,8-Bis(3-tert-butyl-9-acridyl)naphthalene N, N'-dioxide, 1, has been synthesized in five steps from 3-tert-butylaniline and 2-chlorobenzoic acid in 29% overall yield. This C 2-symmetric ligand forms a highly fluorescent scandium complex that can be used for enantioselective sensing of chiral amino alcohols. A fluorescence ligand displacement assay that allows accurate measurements of both the total amount and the enantiomeric excess of several amino alcohols at micromolar concentrations is reported.
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