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Glycan Node Analysis: A Bottom-up Approach to Glycomics
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Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

Proteoglycans and human breast cancer

V I Rykova1, E V Grigorieva, A V Chernenko

  • 1Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk.

Bulletin of Experimental Biology and Medicine
|May 7, 2008
PubMed

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Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...