Related Experiment Video
Updated: Jul 5, 2026
Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Ten-year outcomes following traumatic brain injury: a population-based cohort
C M Cameron1, D M Purdie, E V Kliewer
1School of Medicine, Griffith University, Logan, Australia.
Primary Objective:
To quantify the 10 year health service use (HSU) and mortality outcomes for people with a traumatic brain injury (TBI).
Research Design:
A population-based matched cohort study using linked administrative data from Manitoba, Canada (Manitoba Injury Outcome Study).
Methods And Procedures:
An inception cohort (1988-1991) of hospitalized cases with TBI aged 18-64 years (n = 1290) was identified and matched to a non-injured comparison group (n = 1290). Survival analysis, Negative binomial and Poisson regression were used to quantify associations between injury and HSU/mortality outcomes for 10 years following the TBI event.
Main Outcome And Results:
The majority of deaths (47.2%) occurred in the first 60 days following injury. Excluding the first 60 days, the adjusted 10 year mortality remained elevated (mortality rate ratio = 1.48, 95% CI = 1.02-2.15). After adjusting for demographic characteristics and pre-existing health status, the TBI cohort had more post-injury hospitalizations (rate ratio (RR) = 1.54, 95% CI = 1.39-1.71), greater cumulative lengths of stay (RR = 5.14, 95% CI = 3.29-8.02) and a greater post-injury physician claims rate (RR = 1.44, 95% CI = 1.35-1.53) than the non-injured cohort.
Conclusions:
People who sustain a TBI and survive the initial acute phase of care experience substantially increased long-term morbidity compared to the general population, regardless of the level of injury severity.
