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Updated: Jul 5, 2026
Time-dependent Increase in the Network Response to the Stimulation of Neuronal Cell Cultures on Micro-electrode Arrays
Published on: May 29, 2017
Prediction of entrainment and 1:1 phase-locked modes in two-neuron networks based on the phase resetting curve method
Sorinel Adrian Oprisan1, Christian Boutan
1Physics and Astronomy Department, College of Charleston, Charleston, South Carolina 29424, USA. oprisns@cofc.edu
Abstract:
This study elaborated a systematic and consistent technique for predicting 1:1 entrainment patterns in two-neuron networks based on the phase resetting curve (PRC). The graphical method of the first-order PRC is intuitive and successfully predicts both the entrained period and the phase difference between neural oscillators. It was found that the shape of the synaptic current is not critical in determining the PRC, but the area of the injected current versus time, which is the exchanged electric charge, is a crucial factor. The PRC-based existence and stability criterion for entrainment is in good agreement with the experimental data.
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