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Related Concept Videos

Immunogold Electron Microscopy01:20

Immunogold Electron Microscopy

Immunoelectron microscopy utilizes immunogold labeling of endogenous proteins with specific antibodies to detect and localize these proteins in cells and tissues. The procedure provides insights into the distribution and quantification of protein under different stimulation conditions offering clues about their functions. Conjugating highly electron-dense gold particles with primary or secondary antibodies allow antigen detection on and within cells, with high resolution and specificity.
Formation of Complex Ions03:45

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...

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Synthesis and crystal structure determination of some asymmetrical and symmetrical CR-type macrocyclic Schiff base complexes, with a single pendant coordinating 2-aminoethyl arm.

Inorganic chemistry·2001
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Antitumor properties of some 2-[(dimethylamino)methyl]phenylgold(III) complexes.

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[N,N-bis(2-hydroxyethyl)dithiocarbamato-S,S']dichlorogold( II).

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Related Experiment Video

Updated: Jul 5, 2026

Luminophore Formation in Various Conformations of Bovine Serum Albumin by Binding of Gold(III)
08:26

Luminophore Formation in Various Conformations of Bovine Serum Albumin by Binding of Gold(III)

Published on: August 31, 2018

Biologically-Active Gold(III) Complexes.

R V Parish1

  • 1Department of Chemistry UMIST Manchester M60 1QD UK.

Metal-Based Drugs
|May 14, 2008
PubMed
Summary

New gold(III) complexes show promise as anticancer agents. Pharmacological testing revealed activity against microbes, fungi, and tumors, with potential applications in cancer therapy.

Area of Science:

  • Inorganic chemistry
  • Medicinal chemistry
  • Pharmacology

Background:

  • Gold(III) complexes represent a novel class of compounds with potential therapeutic applications.
  • Previous research has explored various metal complexes for medicinal purposes, but gold(III) complexes are less studied.
  • The specific gold(III) complex [AuX(2)(damp)] was synthesized and evaluated for its biological activities.

Purpose of the Study:

  • To review the background and results of pharmacological testing of [AuX(2)(damp)] complexes.
  • To evaluate the efficacy of these gold(III) complexes against a range of microbes, fungi, and tumors.
  • To compare the activity and chemistry of the diacetato-complex with cisplatin and present preliminary data for phosphine derivatives.

Main Methods:

  • Pharmacological testing of [AuX(2)(damp)] complexes against microbes, fungi, and tumor cell lines.

More Related Videos

A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions
08:21

A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions

Published on: February 5, 2016

Related Experiment Videos

Last Updated: Jul 5, 2026

Luminophore Formation in Various Conformations of Bovine Serum Albumin by Binding of Gold(III)
08:26

Luminophore Formation in Various Conformations of Bovine Serum Albumin by Binding of Gold(III)

Published on: August 31, 2018

A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions
08:21

A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions

Published on: February 5, 2016

  • In vivo xenograft studies using ZR-1-75 models.
  • Chemical analysis and comparison of the diacetato-complex with cisplatin.
  • Preliminary screening of C,P-chelated tertiary phosphine derivatives of gold(III).

    • Main Results:

    • Successful pharmacological testing of [AuX(2)(damp)] complexes against a broad spectrum of microbes, fungi, and tumors.
    • Demonstrated efficacy in in vivo xenograft models (ZR-1-75).
    • The diacetato-complex exhibited activity and chemical properties similar to cisplatin.
    • Preliminary data for C,P-chelated tertiary phosphine gold(III) derivatives were presented.

    Conclusions:

    • [AuX(2)(damp)] complexes are the first fully evaluated gold(III) compounds with significant pharmacological activity.
    • These complexes show potential as novel therapeutic agents, particularly in oncology.
    • Further investigation into the chemistry and therapeutic potential of gold(III) complexes is warranted.