Related Experiment Video

Updated: Jul 5, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

[Systemic treatment of melanoma. Current clinical trials]

A Hauschild1, K Rass, W Tilgen

  • 1Schwerpunktbereich Dermato-Onkologie und Operative Dermatologie, Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein - Campus Kiel, Kiel, Deutschland. ahauschild@dermatology.uni-kiel.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|May 15, 2008
PubMed

Insights

Malignant melanoma treatment requires urgent clinical trials due to unsatisfactory adjuvant and palliative care outcomes. This overview highlights key trials for high-risk and metastatic melanoma patients.

Area of Science:

  • Oncology
  • Dermatology
  • Clinical Trials

Context:

  • Malignant melanoma is a common and increasing cancer.
  • Current adjuvant and palliative treatments for melanoma yield unsatisfactory results.
  • Standardized treatment guidelines exist in Germany.

Purpose:

  • To identify and review current and planned clinical trials for melanoma.
  • To address the urgent need for optimized treatment strategies and new drug evaluation.
  • To ensure high-risk and metastatic melanoma patients receive standard of care within trials.

Summary:

  • This overview focuses on clinical trials in the adjuvant and palliative settings for melanoma.
  • It emphasizes the need for controlled trials to improve treatment outcomes.
  • The standard of care is crucial for patients in clinical trials for high-risk or metastatic melanoma.

Impact:

  • Aims to optimize standard melanoma treatment approaches.
  • Facilitates the evaluation of novel therapeutic agents for melanoma.
  • Provides insights into ongoing research for improving melanoma patient care.

More Related Videos

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...