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[The relationship between microalbuminuria and coronary artery lesions]

Yan Wang1, Yong Li

  • 1Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University, Shanghai 200092, China. baconyan@citiz.net

Zhonghua Nei Ke Za Zhi
|May 16, 2008
PubMed

Insights

Microalbuminuria indicates more severe coronary artery disease in both diabetic and non-diabetic patients. Screening for microalbuminuria can identify patients with worse prognosis in coronary heart disease.

Area of Science:

  • Cardiology
  • Nephrology
  • Diabetology

Background:

  • Coronary heart disease (CHD) remains a leading cause of mortality worldwide.
  • Microalbuminuria (MA) is an early marker of kidney damage and is increasingly recognized as a cardiovascular risk factor.
  • The association between MA and coronary artery stenosis severity requires further elucidation, particularly in diverse patient populations.

Purpose of the Study:

  • To investigate the relationship between microalbuminuria and the extent and severity of coronary artery stenosis in patients with established coronary heart disease.
  • To identify microalbuminuria as a potential predictor of advanced coronary artery lesions.

Main Methods:

  • A cohort of 169 patients with coronary artery disease was divided into diabetic (DM) and non-diabetic groups.
  • Coronary angiography (CAG) and echocardiography were performed. Urinary albumin-to-creatinine ratio (MA) was measured.
  • Coronary artery stenosis severity was assessed using the number of diseased vessels and the AHA coronary artery stenosis score. Stepwise multiple regression analysis identified independent predictors.

Main Results:

  • In both non-DM and DM groups, patients with microalbuminuria exhibited significantly higher coronary artery stenosis scores and a greater number of diseased vessels compared to those without MA (P < 0.05).
  • In the non-DM group, MA, male gender, LDL-C, and EF were independent predictors of coronary artery stenosis score.
  • In the DM group, MA and male gender were identified as independent predictors of coronary artery stenosis score.

Conclusions:

  • Microalbuminuria is significantly associated with more severe coronary artery lesions in patients with coronary heart disease, irrespective of diabetes status.
  • Screening for microalbuminuria in CHD patients can aid in identifying individuals with severe coronary artery disease and a potentially worse prognosis.
  • MA serves as a valuable biomarker for risk stratification in patients with coronary heart disease.
Abstract

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