Related Experiment Video
Updated: Jul 5, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Adrenergic urticaria in a patient with anti-double-stranded DNA antibodies
Adele Chedraoui1, Imad Uthman, Ossama Abbas
1Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
Abstract:
Adrenergic urticaria, a rare but distinct subtype of the physical urticarias, is characterized by wheals that are typically surrounded by a white halo of vasoconstriction, and by a positive response to intradermal adrenaline and noradrenaline injections. The pathogenesis of adrenergic urticaria is unknown. We report here a case of a 64-year-old woman with adrenergic urticaria who was found to have high levels of anti-double-stranded DNA antibodies without features of systemic lupus erythematosus. This is the first report associating adrenergic urticaria with anti-double-stranded DNA antibodies. The significance of this association is unknown.
Related Concept Videos
Hypersensitivity Reactions: Immune-Complex Reactions
Allergic Reactions: Anaphylaxis
Drug Toxicity: Allergic Reactions
Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Hypersensitivity Reactions: Cytolytic Reactions
Allergic Drug Reactions

