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Related Experiment Video

Updated: Jul 5, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Default-mode function and task-induced deactivation have overlapping brain substrates in children.

Moriah E Thomason¹, Catherine E Chang, Gary H Glover

¹Department of Psychology, Stanford University, Jordan Hall, Building 420, Stanford, CA 94305-2130, USA. moriah@stanford.edu

|May 17, 2008

Summary

This summary is machine-generated.

The default-mode network (DMN) in children aged 7-12 shares brain regions with adults, showing similar task-related decreases and resting activity. This suggests resource reallocation is a core developmental process before adolescence.

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Area of Science:

Neuroscience
Developmental Neuroscience
Cognitive Neuroscience

Background:

The default-mode network (DMN) is functionally connected during rest and shows decreased activity during cognitive tasks in adults.
Few studies have investigated the DMN in children, and none have directly compared resting-state DMN regions with task-induced deactivation regions in this age group.

Purpose of the Study:

To identify brain regions exhibiting both task-related decreases and spontaneous resting activity in children.
To examine the co-localization and developmental similarities/differences of the DMN between children (7-12 years) and adults.
To investigate whether task-induced deactivations and resting-state activity in children share common neural substrates.

Main Methods:

Utilized independent component analysis to map the resting-state DMN in children.
Employed parametric modulation of cognitive load to identify task-induced decreases in blood-oxygen-level-dependent (BOLD) signals.
Examined the overlap and co-localization of resting-state DMN regions and task-deactivated regions.

Main Results:

Identified common neural substrates for task-induced deactivations and default-mode resting-state activity in 7-12-year-old children.
Demonstrated similarities and differences in the DMN between children and adults.
Found that task-induced deactivation in children involves reallocating processing resources active at rest, even before adolescence.

Conclusions:

The findings suggest that the default-mode network in children shares core characteristics with adults, indicating a fundamental role in cognitive processing.
Task-induced deactivation appears to involve a consistent mechanism of resource reallocation from a resting state, present early in development.
Future research should consider these networks as part of a continuous developmental system to better understand their evolution.