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Published on: October 12, 2018
[Histiocytic necrotizing lymphadenitis: report of three cases]
Patricio Gac E1, Patricio Cabané T, Carmen Franco S
1Departamento de Cirugía y Anatomía Patológica, Hospital Clínico, Universidad de Chile, Santiago de Chile. patriciogac@yahoo.com.ar
Revista Medica De Chile
|May 17, 2008
Summary
Histiocytic necrotizing lymphadenitis (HNL), a rare condition, presents as cervical lymphadenopathy. Early diagnosis via biopsy is crucial to differentiate it from lymphoma and avoid unnecessary treatments.
Area of Science:
- Pathology
- Oncology
Background:
- Histiocytic necrotizing lymphadenitis (HNL), also known as Kikuchi disease, is a rare, idiopathic condition.
- It typically manifests as cervical lymphadenopathy, fever, and malaise.
Observation:
- This report details three cases of HNL in young women presenting with painless cervical masses.
- Diagnostic challenges include differentiating HNL from reactive lymphadenopathy and malignant tumors like lymphoma.
Findings:
- Excision biopsy confirmed HNL in all three cases.
- Immunohistochemistry was essential in ruling out lymphoma in two patients.
- The condition demonstrated a self-limited clinical course with spontaneous resolution.
Implications:
- HNL should be considered in the differential diagnosis of asymptomatic cervical masses.
- Awareness among clinicians can prevent misdiagnosis and unnecessary, costly treatments.
- Accurate diagnosis avoids prolonged and potentially harmful therapeutic interventions.
