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Updated: Jul 5, 2026
06:33
Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
Avian amyloidosis.
W J Landman1, E Gruys, A L Gielkens
1Animal Health Service, Poultry Health Centre, Deventer.
Avian Pathology : Journal of the W.V.P.A
|May 17, 2008
Summary
Avian amyloidosis, a fatal disease in birds, involves AA-type amyloid deposits. Prevention through hygiene and stress reduction is crucial as no cure currently exists.
Area of Science:
- Veterinary Pathology
- Biochemistry
- Molecular Biology
Background:
- Amyloid deposits, proteinaceous and fibrillar, have been studied for over 150 years.
- Amyloidosis is a recognized pathological disorder and cause of death in various bird species, particularly waterfowl and Galliformes.
- Avian amyloidosis is classified as AA-type amyloid, also known as reactive or secondary amyloid.
Purpose of the Study:
- To review the current understanding of avian amyloidosis, focusing on AA-type amyloid.
- To explore the pathogenesis of amyloidosis, including the role of serum amyloid A (SAA).
- To highlight diagnostic methods and emphasize preventive strategies for avian amyloidosis.
Main Methods:
- Review of existing literature on avian amyloidosis.
- Analysis of biochemical characterization of amyloid.
- Discussion of diagnostic approaches including histopathology.
Main Results:
- Several unrelated proteins can form amyloid fibrils.
- Chronic conditions like infections, inflammation, or tumors elevate serum amyloid A (SAA) levels, the precursor to AA amyloid.
- While increased precursor protein and specific amino acid changes may contribute, other factors are vital for fibril formation.
Conclusions:
- AA-amyloidosis is a progressive and fatal disease in birds.
- Diagnosis relies on histopathology due to non-specific clinical signs.
- Prevention, focusing on hygiene and stress reduction, is paramount due to the lack of curative treatments.
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