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Systemic inflammation after inspiratory loading in chronic obstructive pulmonary disease
Antonia Fuster1, Jaume Sauleda, Ernest Sala
1Serveis de Pneumologia, Hospital Universitari Son Dureta, Fundación Caubet-Cimera, Mallorca, Spain.
Summary
Patients with chronic obstructive pulmonary disease (COPD) have systemic inflammation. Maximal inspiratory loading did not increase pro-inflammatory cytokines in COPD patients, suggesting a blunted anti-inflammatory response.
Area of Science:
- Pulmonary Medicine
- Immunology
- Exercise Physiology
Background:
- Chronic obstructive pulmonary disease (COPD) is characterized by systemic inflammation.
- Strenuous resistive breathing can induce systemic inflammation in healthy individuals.
Purpose of the Study:
- To investigate if the increased respiratory load in COPD contributes to systemic inflammation.
- To compare inflammatory markers in COPD patients and healthy controls before and after maximal inspiratory loading.
Main Methods:
- Compared leukocyte counts and circulating cytokine levels (TNF-alpha, IL-1beta, IL-6, IL-8, IL-10) in 13 COPD patients and 8 healthy controls.
- Measurements were taken before and 1 hour after maximal incremental inspiratory loading.
Main Results:
- COPD patients exhibited higher baseline leukocyte counts and IL-8 levels than controls.
- Maximal inspiratory loading did not alter these pro-inflammatory markers in either group.
- Interleukin-10 (IL-10) increased in controls post-loading but not in COPD patients.
Conclusions:
- Confirms systemic inflammation in COPD.
- Maximal inspiratory loading does not elevate pro-inflammatory cytokines in COPD.
- Suggests COPD patients may have an impaired systemic anti-inflammatory response to exercise.
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