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Updated: Jul 5, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilic esophagitis in adults.
Ganapathy A Prasad1, Nicholas J Talley
1Division of Gastroenterology and Hepatology, Alfred Main, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. prasad.ganapathy@mayo.edu
Gastroenterology Clinics of North America
|May 24, 2008
Summary
Eosinophilic esophagitis (EoE) is a growing esophageal condition causing difficulty swallowing. Diagnosis involves esophageal biopsies, and while steroids are effective treatments, endoscopic procedures carry risks.
Area of Science:
- Gastroenterology
- Immunology
- Pathology
Background:
- Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disease.
- Characterized by eosinophilic infiltration of the esophageal mucosa.
- Increasingly recognized in developed nations, with rising case reports.
Purpose of the Study:
- To summarize the key aspects of eosinophilic esophagitis in adults.
- To highlight diagnostic criteria and treatment options.
- To note potential complications associated with endoscopic interventions.
Main Methods:
- Review of existing literature and case series on EoE.
- Analysis of diagnostic standards, including biopsy findings (≥15 eosinophils/hpf).
- Evaluation of reported treatment outcomes and risks.
Main Results:
- EoE presents with dysphagia and food impactions.
- Diagnosis confirmed by esophageal biopsy with significant eosinophil counts.
- Steroid therapy (systemic and topical) shows treatment success.
- Endoscopic treatments are linked to increased risks of esophageal tears and perforations.
Conclusions:
- Eosinophilic esophagitis is a significant clinical entity in adults.
- Accurate diagnosis relies on histological examination of esophageal biopsies.
- Steroids represent a primary therapeutic approach, while endoscopic interventions require careful consideration due to associated risks.
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