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Related Concept Videos

Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

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Related Experiment Video

Updated: Jul 5, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

Autoimmune pancreatitis.

Timothy B Gardner1, Suresh T Chari

  • 1Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN 55905, USA.

Gastroenterology Clinics of North America
|May 24, 2008
PubMed
Summary
This summary is machine-generated.

Autoimmune pancreatitis is an immune-mediated pancreatic disease affecting multiple organs. It is characterized by a swift response to corticosteroid therapy, improving understanding of its prognosis and treatment.

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A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
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Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
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Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

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Related Experiment Videos

Last Updated: Jul 5, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Area of Science:

  • Gastroenterology
  • Immunology
  • Systemic Diseases

Background:

  • Autoimmune pancreatitis (AIP) is a distinct form of chronic pancreatitis.
  • It involves immune-mediated pancreatic damage and can affect other organs like bile ducts, kidneys, and salivary glands.
  • AIP is increasingly recognized for its unique clinical and histological features.

Purpose of the Study:

  • To describe the characteristics of autoimmune pancreatitis.
  • To highlight its systemic nature and unique features.
  • To emphasize its responsiveness to corticosteroid treatment.

Main Methods:

  • Review of existing literature on autoimmune pancreatitis.
  • Analysis of clinical, histological, and morphological characteristics.
  • Evaluation of treatment responses, particularly to corticosteroids.

Main Results:

  • Autoimmune pancreatitis affects multiple organs beyond the pancreas.
  • It is characterized by unique histological and morphological findings.
  • A rapid and positive response to corticosteroid treatment is a key feature.

Conclusions:

  • Autoimmune pancreatitis is an immune-mediated systemic disorder.
  • Its recognition is growing, leading to better understanding of its clinical course.
  • Corticosteroid therapy is a hallmark treatment for autoimmune pancreatitis.