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Nutritional deficit as a negative prognostic factor in patients with miliary tuberculosis
1Dept of Internal Medicine, Seoul National University Boramae Hospital, Republic of Korea.
The European Respiratory Journal
|May 30, 2008
Summary
Malnutrition significantly predicts poor outcomes in miliary tuberculosis (MTB). A high nutritional risk score (NRS) independently forecasts acute respiratory failure (ARF) and mortality in MTB patients, highlighting the need for nutritional support.
Area of Science:
- Infectious Diseases
- Pulmonology
- Nutritional Science
Background:
- Miliary tuberculosis (MTB) outcomes are poorly understood, especially concerning malnutrition.
- Nutritional status significantly impacts patient prognosis in severe infections.
Purpose of the Study:
- To identify predictors of acute respiratory failure (ARF) and survival in miliary tuberculosis (MTB) patients.
- To evaluate the role of nutritional parameters in MTB prognosis.
Main Methods:
- Retrospective analysis of 56 microbiologically/histopathologically confirmed MTB patients.
- Development of a four-point nutritional risk score (NRS) based on BMI, albumin, cholesterol, and lymphocyte count.
- Assessment of risk factors for ARF, fatality, and 90-day survival.
Main Results:
- A high NRS (≥3) was an independent risk factor for ARF and fatality.
- ARF, low BMI, low cholesterol, lymphocytopenia, and high NRS predicted poor 90-day survival.
- High NRS was the sole independent predictor of poor 90-day survival in multivariate analysis.
Conclusions:
- A high nutritional risk score is a strong predictor of adverse outcomes in miliary tuberculosis.
- Addressing nutritional deficits may be crucial for improving management and survival in MTB patients.
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