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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

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A novel fibrinogen mutation: <i>FGA</i> g. 3057 C > T (p. Arg104 > Cys) impairs fibrinogen secretion.

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Episodic replacement of clotting factor concentrates does not prevent bleeding or musculoskeletal damage - the MUSFIH study.

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Favourable impact of regular swimming in young people with haemophilia: experience derived from 'Desafio del Caribe' project.

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Musculoskeletal evaluation in severe haemophilia A patients from Latin America.

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Identification of factor VIII gene mutations in patients with severe haemophilia A in Venezuela: identification of seven novel mutations.

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A study of reported factor IX use around the world.

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Predictors and Clinical Impact of Time to Diagnosis in Acquired Haemophilia A: An 11-Year Retrospective Cohort Study.

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Male Range of Motion Norms in the Haemophilia Joint Health Score Underrepresent the Severity of Joint Damage in Females.

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Related Experiment Video

Updated: Jul 4, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Laboratory issues in bleeding disorders.

F Rodeghiero1, A Ruiz-Sáez, P H B Bolton-Maggs

  • 1Department of Cell Therapy and Hematology, Hemophilia and Thrombosis Center, San Bortolo Hospital, Vicenza, Italy. rodeghiero@hemato.ven.it

Haemophilia : the Official Journal of the World Federation of Hemophilia
|June 25, 2008
PubMed
Summary
This summary is machine-generated.

Global laboratory diagnostics for bleeding disorders show progress, with most hemophilia and rare bleeding disorder cases appropriately diagnosed. However, von Willebrand

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The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
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The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

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Last Updated: Jul 4, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
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The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

Area of Science:

  • Hematology
  • Clinical Diagnostics
  • Global Health

Background:

  • Accurate diagnosis of inherited bleeding disorders is crucial for patient management.
  • Challenges exist in standardizing laboratory testing worldwide.
  • Haemophilia A and B, von Willebrand's disease (VWD), and rare bleeding disorders (RBD) require specific diagnostic approaches.

Purpose of the Study:

  • To assess the global landscape of laboratory diagnostics for inherited bleeding disorders.
  • To identify areas of strength and weakness in diagnostic capabilities across different regions.
  • To highlight needs for improved standardization and accessibility of diagnostic tests.

Main Methods:

  • Review of selected laboratory issues critical for diagnosing haemophilia A and B, VWD, and RBD.
  • Worldwide perspective analysis of diagnostic capabilities.
  • Consideration of training workshops and minimal diagnostic requirements.

Main Results:

  • Most haemophilia cases are appropriately diagnosed globally, including in Latin America.
  • Training workshops are enhancing diagnostic capabilities for less severe disorders.
  • RBD can often be diagnosed with simple tests if clinical suspicion is high.
  • VWD and platelet function disorders lack diagnostic standardization, limiting capabilities worldwide.

Conclusions:

  • Global diagnostic capabilities for haemophilia and RBD are generally adequate.
  • Significant improvements are noted due to training initiatives.
  • Standardization of diagnostic tests for VWD and platelet function disorders is urgently needed.