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Updated: Feb 7, 2026

GPI Anchoring of Proteins in the ER Membrane
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Chromatin proteins do double duty.

Sevinc Ercan1, Jason D Lieb

  • 1Department of Biology and Carolina Center for the Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Cell
|May 31, 2008
PubMed
Summary
This summary is machine-generated.

The histone acetyltransferase MOF is crucial for X chromosome gene regulation in Drosophila. It binds autosomes and the X chromosome in both sexes for gene regulation, and specifically in males for dosage compensation.

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Area of Science:

  • Genetics
  • Molecular Biology
  • Epigenetics

Background:

  • The histone acetyltransferase MOF (males-absent-on-the-first) is known to regulate X chromosome gene dosage compensation in Drosophila males.
  • MOF's broader role in gene regulation across different chromosomes and sexes was not fully understood.

Purpose of the Study:

  • To investigate the localization and function of MOF beyond its role in male X chromosome dosage compensation.
  • To determine if MOF participates in autosomal gene regulation and if its function differs between sexes.

Main Methods:

  • Chromatin immunoprecipitation (ChIP) to identify MOF binding sites on chromosomes.
  • Analysis of gene expression patterns in male and female Drosophila.

Main Results:

  • MOF is found to bind to both X chromosomes and autosomes in Drosophila.
  • Two distinct modes of MOF binding were identified: one specific to male X chromosome dosage compensation and another, present in both sexes, involved in regulating both X-linked and autosomal genes.
  • This second mode of regulation is independent of dosage compensation.

Conclusions:

  • MOF plays a dual role in Drosophila gene regulation.
  • Beyond its established function in male dosage compensation, MOF is also involved in broader gene expression control on both X chromosomes and autosomes in a sex-independent manner.