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Published on: January 28, 2020

Circulating CXCL16 is related to the severity of coronary artery stenosis

Gui-Wen Yi1, Qiu-Tang Zeng

  • 1Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, PR China.

Archives of Medical Research
|June 3, 2008
PubMed

Insights

Plasma levels of chemokine CXCL16 are elevated in acute coronary syndrome patients and correlate with coronary artery stenosis severity. CXCL16 shows potential as a biomarker for coronary artery disease (CAD).

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Biomarker Discovery

Background:

  • The chemokine CXCL16 is implicated in atherosclerosis and coronary artery disease (CAD).
  • The precise role of CXCL16 in atherosclerosis pathogenesis requires further elucidation.
  • This study investigates the association between CXCL16 levels and the extent of coronary artery stenosis.

Purpose of the Study:

  • To determine the relationship between plasma CXCL16 concentrations and the severity of coronary artery stenosis in patients.
  • To evaluate CXCL16 as a potential biomarker for CAD.

Main Methods:

  • Plasma CXCL16 levels were measured using ELISA in 16 stable angina pectoris (SAP) patients, 53 acute coronary syndrome (ACS) patients, and 19 controls.
  • Patients underwent coronary angiography and were stratified into quartiles based on CXCL16 levels.
  • Correlations between CXCL16 levels, clinical characteristics, and Gensini scores were analyzed.

Main Results:

  • CXCL16 levels were significantly higher in ACS patients compared to controls and SAP patients (p <0.01 and p <0.05, respectively).
  • Gensini scores progressively increased across CXCL16 quartiles, with the highest quartile showing significantly greater stenosis than the lowest (p <0.001).
  • CXCL16 levels demonstrated a significant positive correlation with Gensini scores (r = 0.519, p <0.001).

Conclusions:

  • Plasma CXCL16 levels are positively associated with the severity of coronary artery stenosis.
  • CXCL16 activity in human plasma may serve as a valuable biomarker for epidemiological and clinical applications in CAD.
Abstract

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