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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Updated: Jul 4, 2026

Prostaglandin Extraction and Analysis in Caenorhabditis elegans
08:50

Prostaglandin Extraction and Analysis in Caenorhabditis elegans

Published on: June 25, 2013

Prostanoid and isoprostanoid pathways in atherogenesis.

Domenico Praticò1

  • 1Department of Pharmacology, Temple University School of Medicine, 3420 North, Broad Street, MRB, room 706A, Philadelphia, PA 19140, USA.

Atherosclerosis
|June 3, 2008
PubMed
Summary

This review explores how prostanoids and isoprostanoids, bioactive lipids, contribute to atherosclerosis. Understanding these molecules and their receptors offers insights into cardiovascular disease mechanisms.

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A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

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Last Updated: Jul 4, 2026

Prostaglandin Extraction and Analysis in Caenorhabditis elegans
08:50

Prostaglandin Extraction and Analysis in Caenorhabditis elegans

Published on: June 25, 2013

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Area of Science:

  • Cardiovascular Biology
  • Lipid Metabolism
  • Inflammatory Diseases

Background:

  • Atherosclerosis is a complex vascular disease involving blood components and arterial walls.
  • Bioactive lipids, including prostanoids and isoprostanoids, play significant roles in atherogenesis.
  • These lipids are derived from arachidonic acid through enzymatic or free-radical oxidation pathways.

Purpose of the Study:

  • To review the biological roles of prostanoids, isoprostanoids, and their receptors in atherosclerosis.
  • To integrate current knowledge of cellular mechanisms with experimental findings.
  • To highlight the therapeutic potential of modulating these lipid pathways.

Main Methods:

  • Literature review integrating basic science and experimental studies.
  • Analysis of genetic and pharmacologic studies.
  • Focus on cellular mechanisms and receptor interactions.

Main Results:

  • Prostanoids and isoprostanoids are key lipid mediators in vascular inflammation.
  • Their biosynthesis pathways are altered in atherosclerosis.
  • Specific receptors mediate their biological activities in target cells.

Conclusions:

  • Prostanoids and isoprostanoids are critical players in the development of atherosclerosis.
  • Targeting these lipid mediators and their receptors presents potential therapeutic strategies.
  • Further research is needed to fully elucidate their roles in cardiovascular health.