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Related Concept Videos

Ethics in Research01:56

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
Ethical Issues01:27

Ethical Issues

Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
Ethical Dilemmas I01:17

Ethical Dilemmas I

Ethical dilemmas in nursing are of utmost importance, as they often arise from the tension between adhering to core ethical principles and the practical realities of healthcare delivery. These dilemmas require nurses to navigate complex situations where competing ethical considerations pull them in different directions.
Let us explore some examples to understand the potentially complex moral decisions nurses face.
Take the case of caring for minors, particularly in areas related to reproductive...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

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Updated: Jun 30, 2026

Electrophysiological Measurements and Analysis of Nociception in Human Infants
09:18

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Published on: December 20, 2011

Ethics in neonatal pain research.

Anna Axelin1, Sanna Salanterä

  • 1University of Turku, Turku, Finland. anna.axelin@utu.fi

Nursing Ethics
|June 3, 2008
PubMed
Summary

Ethical reporting in newborn pain research is insufficient. Many studies inadequately address parental consent and pain management, indicating a need for stronger ethical guidelines in clinical research.

Area of Science:

  • Neonatal research ethics
  • Clinical pain studies
  • Scientific publication ethics

Background:

  • Ethical considerations are paramount in all research involving human participants, especially vulnerable populations like newborn infants.
  • Previous research has highlighted variability in ethical reporting standards across different scientific disciplines.
  • Ensuring robust ethical oversight is crucial for maintaining public trust in scientific endeavors.

Purpose of the Study:

  • To evaluate the reporting of ethical issues in clinical pain research involving newborn infants.
  • To assess the guidance provided by scientific journals on ethical reporting for such studies.
  • To identify gaps and deficiencies in the ethical considerations presented in published research.

Main Methods:

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Electrophysiological Measurement of Noxious-evoked Brain Activity in Neonates Using a Flat-tip Probe Coupled to Electroencephalography
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  • A systematic literature review was conducted.
  • Analysis encompassed 98 articles on newborn infant pain research published in 49 scientific journals.
  • Data extraction focused on the reporting of ethical issues, including parental informed consent and ethical review board approval.

    • Main Results:

    • Parental informed consent was reported in 94% of studies, and ethical review approval in 87%.
    • A significant proportion (75%) of studies involved infants experiencing pain due to inadequate pain management or placebo use.
    • Discussion of the risk-benefit balance for participants was notably absent in many articles.
    • One-quarter of the journals lacked specific ethical guidelines for manuscript submissions.

    Conclusions:

    • Ethical considerations appear to play a limited role in the analyzed newborn pain research.
    • Inconsistent and superficial ethical guidelines in journals may permit studies with questionable ethical foundations.
    • There is a critical need for enhanced ethical scrutiny and reporting standards in neonatal pain research to protect vulnerable infant participants.