Related Experiment Video
Updated: Jul 4, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
Analysis of the lipid profile of elderly women in Curitiba - Parana
Maressa P Krause1, Tatiane Hallage, Cristiane Petra Miculis
1University of Pittsburgh, PA, United States. maressakrause@hotmail.com
Insights
Many elderly women have poor lipid profiles, even when on treatment. This study highlights the need for better dyslipidemia management in older women, particularly those with cardiovascular disease (CVD).
Area of Science:
- Cardiology
- Geriatrics
- Public Health
Background:
- Dyslipidemia is a major risk factor for cardiovascular disease (CVD), especially in the elderly.
- Many older adults are unaware of their lipid status or lack adequate treatment.
- CVD prevalence increases with age, making lipid management crucial.
Purpose of the Study:
- To assess the lipid profiles of elderly women in Curitiba, Brazil.
- To determine the utilization of lipid-lowering therapies in this demographic.
- To identify gaps in dyslipidemia management among older women.
Main Methods:
- Study included 312 women (mean age 68.8 years).
- Lipid profiles measured via plasma levels of total cholesterol (TC), HDL-C, LDL-C, and triglycerides (TG).
- Participants self-reported lipid-lowering therapy use, dividing them into satisfactory and unsatisfactory groups.
Main Results:
- High prevalence of unsatisfactory lipid levels observed, particularly in women not on therapy.
- 74.2% of women with CVD on no therapy exceeded LDL-C goals.
- Even among those on therapy, 45.8-49.3% had unsatisfactory TC, TG, and LDL-C levels, with 25.4% having low HDL-C.
Conclusions:
- Elderly women frequently exhibit unsatisfactory lipid profiles, irrespective of therapy.
- LDL-C goals are often unmet, especially in women with CVD.
- This underscores a significant need for improved dyslipidemia screening and treatment in elderly women.
Background:
Dyslipidemia is considered one of the main risk factors for cardiovascular disease (CVD), which is more frequent in older individuals. However, evidence suggests that a large number of elderly individuals is not aware of their lipid profile status; additionally, many of them do not have access to adequate treatment.
Objective:
To analyze the lipid profile and the frequency of lipid-lowering therapy use in elderly women from the city of Curitiba, state of Parana, Brazil.
Methods:
The sample consisted of 312 women (mean age = 68.8; SD = 6.0 years). The lipid profile was determined by plasma levels of total cholesterol (TC), high-density cholesterol (HDL-C), low-density cholesterol (LDL-C) and triglycerides (TG). The number of subjects that reported being on lipid-lowering therapy was self-reported; therefore, the groups were divided into two subgroups, satisfactory and unsatisfactory.
Results:
A high prevalence of individuals with unsatisfactory levels of lipid profile components was observed in the group that self-reported not being on lipid-lowering therapy; of these, 74.2% of women with CVD presented levels above the LDL-C goal. On the other hand, 45.8 to 49.3% of the individuals from the group that self-reported being on lipid-lowering therapy had unsatisfactory values of TC, TG and LDL-C, and 25.4% had HDL-C levels lower than 40.0 mg/dl.
Conclusion:
The results of this investigation indicate a high prevalence of elderly women, regardless of self-reports of being on lipid-lowering therapy, with an unsatisfactory lipid profile, mainly related to LDL-C goal for those individuals with CVD.
Related Concept Videos
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Lipid Digestion
Lipid Absorption
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
