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Updated: Jul 4, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Cell traffic and the lymphatic endothelium.
Louise A Johnson1, David G Jackson
1MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.
Annals of the New York Academy of Sciences
|June 4, 2008
Summary
Leukocytes migrate into lymphatic capillaries through a complex process involving adhesion molecules and chemokines. This leukocyte trans-lymphatic endothelial migration is crucial for initiating immune responses by transporting antigens to lymph nodes.
Area of Science:
- Immunology
- Cell Biology
- Lymphatic System Research
Background:
- Afferent lymphatic vessels transport antigens and leukocytes from tissues to lymph nodes.
- Leukocyte migration into lymphatic capillaries is a regulated, active process.
Purpose of the Study:
- To review current knowledge on leukocyte trans-lymphatic endothelial migration.
- To highlight the role of this process in immune response development.
Main Methods:
- Literature review of recent research on leukocyte migration.
- Analysis of molecular mechanisms (adhesion molecules, chemokines, receptors).
Main Results:
- Leukocyte entry into lymphatic capillaries is orchestrated by specific molecular interactions.
- Adhesion molecules, chemokines, and their receptors mediate this migration.
Conclusions:
- Leukocyte trans-lymphatic endothelial migration is a key, regulated step in immune surveillance.
- Understanding this process is vital for comprehending immune response initiation.
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