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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

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Related Experiment Video

Updated: Jul 4, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Smart polymers for responsive drug-delivery systems.

Tamar Traitel1, Riki Goldbart, Joseph Kost

  • 1Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Journal of Biomaterials Science. Polymer Edition
|June 7, 2008
PubMed
Summary
This summary is machine-generated.

Smart polymers offer advanced drug delivery by mimicking natural body functions. These responsive systems are categorized into externally controlled and self-regulated types for targeted therapeutic effects.

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Polymer Chemistry

Background:

  • Biocompatible polymers are increasingly utilized in biomedical research.
  • Modern medicine aims to replicate healthy physiological functions for healing.
  • This has driven the development of smart polymers for responsive drug delivery.

Purpose of the Study:

  • To review the advancements in smart polymers for drug delivery.
  • To categorize these systems into externally regulated and self-regulated types.
  • To outline the mechanisms employed by each category.

Main Methods:

  • Categorization of drug delivery systems into open-loop and closed-loop.
  • Identification of external triggers for pulsatile delivery (ultrasonic, magnetic, electric, light, chemical/biochemical).
  • Description of feedback-controlled mechanisms in self-regulated systems.

Main Results:

  • Externally regulated systems use external triggers for drug release.
  • Self-regulated systems adjust output based on detected variables without external intervention.
  • Self-regulated systems employ mechanisms like thermal, pH-sensitivity, enzyme-substrate reactions, and others for rate control.

Conclusions:

  • Smart polymers represent a significant advancement in drug delivery.
  • Both externally regulated and self-regulated systems offer distinct advantages.
  • Self-regulated systems provide autonomous control over drug release rates via feedback mechanisms.