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Published on: January 7, 2019
[Pathway analysis of modulation on gene expression in murine lymphocytes by Lactobacillus peptidoglycan]
Jin Sun1, Gui-fang Chang, Guo-wei LE
1Southern Yangtze University, Wuxi, China. sunj@jiangnan.edu.cn
Aim:
To investigate the mechanism that Lactobacillus peptidoglycan modulates mice immune response.
Methods:
BALB/c mice were administrated (i.p.) with Lactobacillus peptidoglycan once or three times. Peritoneal macrophages and spleen lymphocytes were isolated for gene expression analysis using gene array. PathwayExplorer and GeneMAPP were used to explore significant pathway in database.
Results:
The analysis resulted in five significant pathways: cytokine-cytokine receptor interaction, T helper cell surface molecules, ribosomal proteins, inflammatory response pathway and mm heme biosynthesis.
Conclusion:
Lactobacillus peptidoglycan induced expression of considerable genes, which related to protective immune response and activation of Th cells. The induced immune response might be Th1 type.
