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Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
Published on: May 12, 2020
Oxidative stress markers in bipolar disorder: a meta-analysis
Ana C Andreazza1, Marcia Kauer-Sant'anna, Benicio N Frey
1Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Journal of Affective Disorders
|June 10, 2008
Summary
Oxidative stress markers, including TBARS and NO, are elevated in bipolar disorder (BD). This meta-analysis suggests oxidative stress plays a role in BD pathophysiology, though antioxidant enzyme levels showed no significant changes.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Background:
- Oxidative stress is implicated in the neuropathology of neuropsychiatric disorders.
- Emerging evidence suggests a role for oxidative stress in bipolar disorder (BD) pathophysiology.
Purpose of the Study:
- To conduct a meta-analysis of peripheral oxidative stress markers in individuals with BD compared to healthy controls.
- To evaluate the association between oxidative stress and BD.
Main Methods:
- A systematic Medline search identified relevant studies measuring peripheral oxidative stress markers in BD.
- Meta-analysis using a random effects model assessed pooled effect sizes.
- Publication bias and heterogeneity were evaluated using Egger's test and I(2) statistics.
Main Results:
- Significantly increased levels of Thiobarbituric Acid Reactive Substances (TBARS) and nitric oxide (NO) activity were observed in individuals with BD.
- Large effect size for TBARS and moderate effect size for NO increase were noted.
- No significant effect sizes were found for antioxidant enzymes: superoxide dismutase, catalase, and glutathione peroxidase.
Conclusions:
- Meta-analysis indicates elevated oxidative stress markers in BD, supporting its role in the disorder's pathophysiology.
- Caution is advised due to potential publication bias in superoxide dismutase (SOD) studies.
- Further research should consider the balance between antioxidant enzymes rather than absolute values.
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