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Amitriptyline-selective plastic membrane sensors and their pharmaceutical applications
A A Bunaciu1, M S Ionescu, C Pălivan
1Institute of Chemical and Pharmaceutical Research Bucharest, Romania.
The Analyst
|March 1, 1991
Summary
New potentiometric sensors for amitriptyline determination were developed. These sensors offer reliable quantification in pharmaceutical formulations and drug release studies.
Area of Science:
- Analytical Chemistry
- Electrochemistry
- Materials Science
Background:
- Potentiometric sensors offer a sensitive method for drug quantification.
- Developing selective and stable electrodes is crucial for pharmaceutical analysis.
Purpose of the Study:
- To construct and characterize novel potentiometric sensors for amitriptyline.
- To evaluate the sensors' performance in determining amitriptyline hydrochloride in various pharmaceutical contexts.
Main Methods:
- Fabrication of plastic membrane electrodes using ion-pair complexes.
- Performance evaluation including response range, detection limit, and stability.
- Application in the analysis of pure drug substances, pharmaceutical preparations, and tablet formulations.
Main Results:
- Electrodes exhibited near-Nernstian responses from 1 x 10(-2) to 7 x 10(-6) mol dm-3.
- A detection limit of approximately 5 x 10(-6) mol dm-3 was achieved.
- Successful application in determining amitriptyline hydrochloride content and dissolution rates.
Conclusions:
- The developed potentiometric sensors are effective for amitriptyline determination.
- The sensors are suitable for quality control of pharmaceutical products, including content uniformity and dissolution testing.