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High-speed polarization sensitive optical frequency domain imaging with frequency multiplexing.

W Y Oh1, S H Yun, B J Vakoc

  • 1Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 704, Boston, Massachusetts 02114, USA. woh1@partners.org

Optics Express
|June 11, 2008
PubMed
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Polarization-sensitive optical coherence tomography (PS-OCT) offers new insights into vascular tissues by mapping birefringence. This study presents a high-speed intravascular PS-OCT system for in vivo imaging of coronary atherosclerosis.

Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Cardiovascular Research

Background:

  • Polarization-sensitive optical coherence tomography (PS-OCT) provides cross-sectional birefringence images, complementing standard reflectance imaging.
  • Birefringence mapping in ex vivo studies characterizes collagen and smooth muscle in vascular tissues.
  • In vivo PS-OCT could offer new insights into coronary atherosclerosis and acute myocardial infarction.

Purpose of the Study:

  • To develop a high-speed intravascular polarization sensitive optical frequency domain imaging (PS-OFDI) system.
  • To enable percutaneous in vivo birefringence imaging of vascular tissues.
  • To overcome challenges of temporal and spatial variations in fiber-optic catheter-based imaging.

Main Methods:

  • Developed a novel PS-OFDI system using frequency multiplexing.

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  • Simultaneously measured reflectance of two incident polarization states.
  • Utilized a flexible fiber-optic catheter for intravascular imaging.

    • Main Results:

    • Achieved high-speed intravascular birefringence imaging with an A-line rate of 62 kHz.
    • Demonstrated circular cross-sectional birefringence imaging of a human coronary artery ex vivo.
    • System achieved a ranging depth of 6.2 mm.

    Conclusions:

    • The developed PS-OFDI system enables high-speed intravascular birefringence imaging.
    • This technology has potential for in vivo assessment of coronary atherosclerosis.
    • The frequency multiplexing design addresses key challenges in fiber-optic catheter-based PS-OCT.