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Intermediate filament-plasma membrane interactions.

J C Jones¹, K J Green

¹Department of Cell, Molecular and Structural Biology, Northwestern University Medical School, Chicago, Illinois 60611.

Current Opinion in Cell Biology

|February 1, 1991

Summary

This summary is machine-generated.

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This review explores how intermediate filaments connect to desmosomes and hemidesmosomes. It examines molecules mediating these interactions and potential direct binding to membrane components.

Area of Science:

Cell Biology
Biochemistry

Background:

Intermediate filaments provide mechanical stability to cells.
Desmosomes and hemidesmosomes are crucial cell-cell and cell-matrix adhesion structures.

Purpose of the Study:

To review molecules mediating intermediate filament-desmosome and intermediate filament-hemidesmosome interactions.
To explore mechanisms of intermediate filament binding to these structures.
To address potential direct interactions with membrane proteins and lipids.

Main Methods:

Literature review of molecular interactions.
Analysis of protein binding mechanisms.
Examination of biophysical interaction models.

Main Results:

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Identified key adaptor proteins linking intermediate filaments to desmosomes/hemidesmosomes.

Discussed diverse binding strategies, including direct and indirect associations.

Highlighted the role of specific molecular domains in filament integration.

Conclusions:

Intermediate filament-junctional complex interactions are complex and multifactorial.
Understanding these interactions is vital for cell mechanics and tissue integrity.
Further research is needed to fully elucidate direct binding events.