[Systemic and regional hemodynamic reactions to metabolic stress caused by 2-deoxyglucose]

Changes in parameters of systemic and regional hemodynamic, elicited by intraarterial administration of 250 or 500 mg/kg of 2-deoxy-D-glucose (2-DG) were studied in the awake Wistar rats with microsphere technique. Measurements were performed before, 15-and 40-min after 2-DG administration. Significant decrease in the heart rate as well as increase in stroke volume were observed 15 min after 2-DG. It was a tendency to increase in cardiac output. Blood flow in skin and skeletal muscles were decreased whereas in the brain, heart, adrenal glands and small intestine there were significant increases in the blood flow. We conclude that hemodynamic responses to 2-DG reflect the effects of humoral (adrenaline) and central sympathetic factors.